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Background Information:
An Orally active dual inhibitor of the Phosphatidylinositol-3-kinase (PI3K) and the downstream mammalian target of rapamycin (mTOR), displaying potent in vivo antitumor activity.
Reference:
1. Maira, SM., et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther, 2008, 7(7), 1851–1863.
2. J. A. Engelman, et al, Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers, Nature Medicine, 14, 1351-1356 (2008)*Our product NVP-BEZ235 is readily soluble at ROOM TEMPERATURE in N-methyl-2-pyrrolidone (NMP), and DMSO at a concentration at least 10mg/ml.
APIM050207: NVP-BEZ235
CAS No.: 915019-65-7.
Molecular Formula: C30H23N5O.
Molecular Weight: 469.55.
Purity: 99% (HPLC at 214 and 254 nm).
QC: 1HNMR, HPLC and MS.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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