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Conditions of optimal NR1H2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
NR1H2 regulates the metabolism of cholesterol and bile acids. There are 2 subtypes of LXR, LXR-alpha & LXR-beta. NR1H2 is a ligand-dependent transcription factor that forms heterodimer with the retinoid X receptor. LXR- member of Nuclear Receptor Family is triggered by specific oxysterol derivatives of cholesterol. LXRB takes part in cholesterol, lipid, and carbohydrate metabolism. LXRB responds to increasing cholesterol levels via transactivation of genes involved in sterol transport (ABCA1, ABCG1, ABCG5, and ABCG8), cholesterol efflux and high-density lipoprotein (HDL) metabolism, and sterol catabolism (CYP7A1). NR1H2 is involved in regulating cellular lipid content through activation of SREBP-1c, which is the principal regulator of de novo lipogenesis. LXRB upregulates angiopoietin like protein 3 (Angpf13), part of the family of VEGFs that is also a main regulator of lipid metabolism.
BP002930-PRO-869: Recombinant Human Nuclear Receptor Subfamily 1 Group H Member 2 (NR1H2) Protein
Source: Nicotiana benthamiana-derived.
Recombinant Human Nuclear Receptor Subfamily 1 Group H Member 2 (NR1H2) Protein is a single polypeptide chain containing 293 amino acids and having a total molecular mass of 31.9 kDa. The LXRB is fused to 6xHis Tag at N-terminus and purified by proprietary chromatographic techniques.
Purity: >95.0% as determined by SDS-PAGE.
Formulation: Lyophilized from a concentrated (1 mg/ml) solution containing 20 mM Tris Hcl pH 8 & 0.1% SDS.
Reconstitution: It is recommended to reconstitute the lyophilized NR1H2 in sterile water & 50 ug/ml BSA at a concentration of 1 mg/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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