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Conditions of optimal NHEJ1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Non-homologous end-joining factor 1 (NHEJ1) is a member of the XLF family. NHEJ1 is a DNA repair factor vital for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. NHEJ1 gene mutations cause different kinds of severe combined immunodeficiency disorders. NHEJ1 was initially detected as the protein mutated in five patients with growth retardation, microcephaly, and immunodeficiency. In addition, patients with NHEJ1 mutations have immunodeficiency caused by a defect in V(D)J recombination, which employs NHEJ to promote immune system diversity.
BP002934-PRO-1193: Recombinant Human Nonhomologous end-joining factor 1 (NHEJ1) Protein
Source: E. coli-derived.
Recombinant Human Nonhomologous end-joining factor 1 (NHEJ1) Protein is a single polypeptide chain containing 247 amino acids (1-224) and having a molecular mass of 27.8 kDa. Recombinant Human Nonhomologous end-joining factor 1 (NHEJ1) Protein is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Purity: >90% as determined by SDS-PAGE.
Formulation: The NHEJ1 solution (0.5 mg/ml) contains 20 mM Tris-HCl buffer (pH 8.0), 0.1 M NaCl, 1 mM DTT and 20% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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