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Conditions of optimal NEU1 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction:
Sialidase-1, also known as Acetylneuraminyl hydrolase, G9 sialidase, Lysosomal sialidase, N-acetyl-alpha-neuraminidase 1, NEU1 and NANH, belongs to the N-acetyl-a neuraminidase family. NEU1 is expressed in many tissues, highly in pancreas, weakly in brain. NEU1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme NEU1 leads to sialidosis, a rare lysosomal storage disease. NEU1 has been shown to interact with cathepsin A (protective protein), beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
BP001192-ENZ-645: Recombinant Human N-acetyl-alpha-neuraminidase 1 (NEU1)
Source: E. coli-derived.
A single polypeptide chain containing 393 amino acids (48-415) and having a molecular mass of 42.9 kDa. NEU1 is fused to a 25 amino acid His-tag at N-terminus.
Purity > 85%, by SDS-PAGE.
Formulation: The NEU1 solution (0.25 mg/ml) contains 20 mM Tris-HCl buffer (pH 8.0), 0.15 M NaCl, 1 mM DTT and 10% glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other NEU1 Enzymes:
Recombinant Human N-acetyl-alpha-neuraminidase 1
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