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Conditions of optimal NAE1 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
NEDD8-activating enzyme E1 regulatory subunit (NAE1) is a member of the ubiquitin-activating E1 family. NAE1 binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is believed to have a role in the pathogenesis of Alzheimer's disease. NAE1 participates in a unique ubiquitinylation-related pathway involving the ubiquitin-like molecule NEDD8. Furthermore, the NAE1 protein is essential for cell cycle progression through the S/M checkpoint.
BP002592-ENZ-227: Recombinant Human NEDD8 Activating Enzyme E1 Subunit 1 (NAE1)
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 557 amino acids (1-534) and having a molecular mass of 62.7 kDa. NAE1 is fused to a 23 amino acid His-tag at N-terminus.
Purity: > 90% as determined by SDS-PAGE.
Formulation: The NAE1 solution (0.5 mg/ml) contains 20 mM Tris-HCl buffer (pH 8.0), 2 mM DTT, 10% glycerol and 200 mM NaCl.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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