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Background Information:
An orally bioavailable inhibitor of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets VEGF, PDGF, kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.
Reference:
1. Polverino, A., et al., AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts, Cancer Research, 2006, 66 (17), 8715-8721.
2. Sherman, S.I, et al, Motesanib Diphosphate in Progressive Differentiated Thyroid Cancer, N Engl J Med. 2008, 359:31-42.
APIM050204: MOTESANIB DIPHOSPHATE
CAS No.: 857876-30-3.
Molecular Formula: C22H23N5O ? 2(H3PO4).
Molecular Weight: 569.44.
Purity: > 99% (HPLC).
QC: LC/MS, 1HNMR.
Solubility: Soluble in water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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