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Conditions of optimal MMP-1 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Matrix Metalloproteinase-1 (MMP-1) is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages .MMP1 contains several distinct domains: a prodomain which is cleaved upon activation a catalytic domain containing the zinc binding site a short hinge region and a carboxyl terminal (hemopexin like) domain. MMP 1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, ?1 antitrypsin,myelin basic protein, L-Selectin, pro-TNF, IL1, IGFBP3, IGFBP5, pro-MMP2 and pro MMP9. A significant role of MMP1 is the degradation of fibrillar collagens in extracellular matrix remodeling, characterized by the cleavage of the interstitial collagen triple helix into 3/4,1/4 fragments. MMP1 may also involve in enzyme cascades, cytokine regulation and cell surface molecule modulation.
BP001663-ENZ-099: Recombinant Human Matrix Metalloproteinase-1 (MMP-1) Enzyme
Source: HEK 293-derived.
A proform of the Human MMP1 (Met1-Asn469) and fused with a ployhistide tag at the C-terminus, having an Mw of 52 kDa.
The activity was measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2. The specific activity is > 400 pmoles/min/µg.
Purity: > 95% by SDS-PAGE.
Formulation? The MMP-1 is supplied as a 0.2 um filtered solution in MES, NaCl, Glycerol and Brij35.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other MMP-1 Enzymes:
Recombinant Human MMP-1 Enzyme
MMP-1 Antibodies:
MMP-1 Polyclonal Antibody
MMP-1 ELISA Kits:
Human MMP-1 ELISA Kit
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