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Conditions of optimal MMACHC Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Though the exact role of MMACHC is unknown, its C-terminal region shows similarity to TonB, which is a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Therefore, it is suggested that MMACHC may have a role in the binding and intracellular trafficking of cobalamin. MMACHC mutations are linked with methylmalonic aciduria and homocystinuria type cblC. MMACHC is widely expressed, it is expressed at higher level in the fetal liver, however it is also expressed in the spleen, lymph node, thymus and bone marrow. MMACHC is weakly or not expressed in the peripheral blood leukocytes.
BP003013-PRO-1119: Recombinant Human Methylmalonic aciduria and homocystinuria type C protein (MMACHC) protein
Source: E. coli-derived.
Recombinant Human Methylmalonic aciduria and homocystinuria type C protein (MMACHC) protein is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Predicted molecular mass: 32.8 kDa.
Purity: > 90.0% by SDS-PAGE.
Formulation: MMACHC protein solution (0.5 mg/ml) containing 20 mM Tris-HCl buffer (pH 8.0), 0.15 M NaCl, 10% glycerol and 1 mM DTT.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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