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Conditions of optimal MLF1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Myeloid leukemia factor 1 (MLF1) is a member of the MLF family, and is a widely expressed negative regulator of cell cycle progression functioning upstream of the tumor suppressor p53. MLF1 hinders the erythropoietin-induced erythroid terminal differentiation by averting cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. MLF1 generally functions in multi-potent progenitor cells, and its dysregulation may be to some extent responsible for leukemogenesis. Translocations between the MLF1 gene and nucleophosmin are linked to myelodysplastic syndrome and acute myeloid leukemia.
BP003012-PRO-100: Recombinant Human Myeloid Leukemia Factor 1 (MLF1) protein
Source: E. coli-derived.
Recombinant Human Myeloid Leukemia Factor 1 (MLF1) protein is purified by proprietary chromatographic techniques.
Predicted molecular mass: 32.8 kDa.
Purity: > 85.0% by SDS-PAGE.
Formulation: The MLF1 solution (0.5 mg/ml) contains 20 mM Tris-HCl buffer (pH 8.0), 40% glycerol, 5 mM DTT and 200 mM NaCl.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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