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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal MIP 3α Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
CCL-20 is a chemotactic factor that draws lymphocytes & neutrophils, rathar than monocytes. MIP-3 alpha inhibits proliferation of myeloid progenitors in colony formation assays. MIP3A plays a role in the formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. CCL-20 holdes antibacterial activity e.coli atcc 25922 and s.aureus atcc 29213. CCL-20 gene transcription is activated by H. pylori, which activates NF-kappaB through intracellular signal pathway which involves IkappaB kinase and NF-kappaB-inducing kinase. MIP-3 alpha is invloved in chemokine-mediated lymphocyte trafficking during gastric inflammation in Helicobacter infection. CCL-20 expression is involved in the recruitment of CD45R0-positive T cell subsets into the intestinal lamina propria. MIP-3A is in charge of the advancement of pulpal inflammation through the recruitment of C-C motif Receptor 6-expressing lymphocytes Vaginal epithelial cells respond to factors present in semen by secreting MIP-3 alpha, which increases langerhans cells recruitment during HIV transmission.
BP000284-CHM-236: Recombinant Mouse MIP-3 α (CCL20)
Source: E. coli-derived.
A single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 7.9 kDa.
The Activity is calculated by its ability to chemoattract primary human T cells at 2-20 ug/ml, corresponding to a specific activity of 50,000-500,000 units/mg.
Purity > 95%, by SDS-PAGE and RP-HPLC.
Formulation: Lyophilized from a concentrated (1ug/ml) solution in water containing no additives.
Reconstitution: It is recommended to reconstitute the lyophilized MIP-3a in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other MIP 3 alpha Proteins:
Recombinant Human MIP-3 α (CCL20) , His Tag
Recombinant Human MIP-3 α (CCL20)
MIP-3 alpha ELISA Kit:
Rat MIP-3α ELISA Kit
Human MIP-3α ELISA Kit
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