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Introduction
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes (neutrophils, eosinophilsand basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-6 and TNF-alpha from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.
BP000281-CHM-343: Recombinant Rat MIP-1 α (CCL3)
Source: E. coli-derived.
N-terminal sequence analysis: Ala-Pro-Tyr-Gly-Ala.
Predicted molecular mass: 7853 Da.
The activity is calculated by the ability to chemoattract of rat peritoneal macrophages using a conc. of 60 ug/ml corresponding to a Specific Activity of 16,667 IU/mg.
Purity > 97%, by SDS-PAGE and RP-HPLC.
Formulation: Lyophilized from 1 ug/ml solution containing no additives.
Reconstitution: It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-1a in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other MIP-1alpha Proteins:
Recombinant Human MIP-1 α (CCL3), His Tag
Recombinant Mouse MIP-1 α (CCL3)
Recombinant Human MIP-1 α (CCL3) Protein
Recombinant Human MIP-1 α (CCL3)
MIP-1alpha Antibody:
MIP-1α Polyclonal Antibody
MIP-1 alpha ELISA Kit:
Human MIP-1α ELISA Kit
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