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Conditions of optimal MEK1 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Introduction
MAP2K1 is a member of the dual specificity protein kinase family, which plays a role as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, are recognized as extracellular signal-regulated kinases (ERKs), that act as an integration position for multiple biochemical signals. MEK1 is located upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As a key player of MAP kinase signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. MAP2K1 catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a thr-glu-tyr sequence located in map kinases. MEK1 activates erk1 and erk2 map kinases.
BP000837-PKA-256: Recombinant Human Mitogen Activated Kinase Kinase 1 (MEK1)
Source: Sf9 Insect Cells-derived.
A glycosylated, polypeptide chain containing amino acids 2-393 having a molecular mass of 47 kDa.
~125-175 units/mg. One unit of MEK1 activity transfers 1 nmol of phosphate to ERK1/2 peptide per minute at 30C in a reaction containing 100 µM ATP.
Purity > 90%, by SDS-PAGE.
Formulation: MEK1 is supplied at a concentration of 0.09 mg/ml in 40 mM Tris, pH-8, 0.15 M NaCl, 0.27 M sucrose, 1 mM DTT, 0.2 um PMSF, 1 mM benzamidine, 0.1 mM sodium vanadate and 0.03% Brij-35.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
MEK1 Antibodies:
MEK1/2 (Phospho-Ser221) Polyclonal Antibody
MEK1/2 (Phospho-Ser217) Polyclonal Antibody
MEK1/2 (Ab-221) Polyclonal Antibody
MEK1/2 (Ab-217) Polyclonal Antibody
MEK1 Polyclonal Antibody
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