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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal MECP2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
MECP2 is the key modificator of eukaryotic genomes and has a crucial part in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 form a family of nuclear proteins linked by the existence in each of a methyl-CpG binding domain (MBD). Each one of these proteins, with the exception of MBD3, can bind specifically to methylated DNA. In addition, MECP2, MBD1 and MBD2 can inhibit transcription from methylated gene promoters. Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is expendable in stem cells, but is vital for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common reasons of mental retardation in females.
BP002695-PRO-212: Recombinant Human Methyl CpG binding protein 2 (MECP2) protein
Source: Mammalian system, 293 cells-derived.
Recombinant Human Methyl CpG binding protein 2 (MECP2) protein MECP2 Human Recombinant is expressed in 293 cells.
Predicted molecular mass: 53.56 kDa.
Purity: > 80% by SDS-PAGE.
Formulation: The MECP2 solution (0.45 mg/ml) contains 50 mM Tris, 135 mM NaCl, 20% Glycerol, pH 7.5 and 200 ?g/ml FLAG peptide.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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