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Conditions of optimal MAGEA1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Melanoma antigen family A 1 belongs to the MAGEA gene family, whose members encode proteins with 50 to 80% sequence identity to each other. The MAGEA genes which are clustered at chromosomal location Xq28, have been implicated in some hereditary disorders, such as dyskeratosis congenita.
Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs).
Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
BP002322-PRO-311: Recombinant Human Melanoma Antigen Family A 1 (MAGEA1) Protein
Source: E. coli-derived.
Recombinant Human MAGEA1 protein full length protein, MAGEA1 is antibody reactive. The MAGEA1 is fused to a GST tag purified by proprietary chromatographic techniques.
Applications: ELISA; Inhibition Assays; Western Blotting.
Formulation: MAGEA1 in 50 mM Tris-Acetate, pH7.5, 1 mM EDTA and 20% Glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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