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Conditions of optimal Leptin mutant Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
A 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin provides the key afferent signal from fat cells in the feedback system that controls body fat stores.
BP000221-CYT-702: Recombinant Human Leptin Antagonist Triple Mutant Pegylated
Source: E.Coli-derived.
A single non-glycosilated polypeptide chain containing 146 amino and additional Ala at N-terminus acids and having a molecular weight of 35.6 kDa.
Capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. Its in vitro activity is 6-8 fold lower than the non-pegylated antagonist but in vivo it has profound weight gain effect (as compared to the non-pegylated antagonist), resulting mainly from increased food intake. Its in vivo activity compared to that of PEG-MLA is 9-27 fold higher.
Purity > 98.0% by Gel filtration analysis and SDS-PAGE.
Formulation: The protein was lyophilized from a concentrated (0.65 mg/ml) solution with 0.003 mM NaHCO3.
Reconstitution: It is recommended to reconstitute the lyophilized Leptin Antagonist Triple Mutant pegylated Human Recombinant in sterile 0.4% NaHCO3 adjusted to pH 8-9, not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other Leptin Mutant Proteins:
Recombinant Rat Leptin Antagonist Triple Mutant
Recombinant Ovine Leptin Antagonist Triple Mutant Pegylated
Recombinant Ovine Leptin Antagonist Quadruple Mutant
Recombinant Ovine Leptin Antagonist Triple Mutant
Recombinant Mouse Leptin Antagonist Triple Mutant
Recombinant Human Leptin Antagonist Triple Mutant
Recombinant Human Leptin Antagonist Quadruple Mutant
Recombinant Mouse Leptin Antagonist Triple Mutant Pegylated
Recombinant Rat Leptin Antagonist Triple Mutant Pegylated
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