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Background Information:
LDK378(Ceritinib) is a highly selective, orally bioavailable and ATP-competitive small molecule inhibitor of ALK (Anaplastic Lymphoma Kinase), a receptor tyrosine kinase considered to be an important lung cancer drug target. LDK378 displays enhanced potency over Crizotinib and noteworthy antitumor activity for ALK-activated, non-small cell lung cancer (NSCLC).
APIM050179: LDK378 (CERITINIB)
CAS No.: 1032900-25-6.
Molecular Formula: C28H36ClN5O3S.
Molecular Weight: 558.1.
Purity: >99% (by HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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