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Conditions of optimal LAIR1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Leukocyte-associated immunoglobulin-like receptor 1, also known as CD_antigen CD305, LAIR1, is a Single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells, highly in naive T-cells and B-cells. As an inhibitory receptor, LAIR1 plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. LAIR1 plays inhibitory role independently of SH2-containing phosphatases and modulates cytokine production in CD4+ T-cells. It down-regulates IL2 and IFNG production while inducing secretion of transforming growth factor beta, also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. LAIR1 inhibits the differentiation of peripheral blood precursors towards dendritic cells. It also restrains proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.
BP001338-PRO-431: Recombinant Human Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) Protein
Source: Escherichia Coli-derived.
Recombinant Human Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) Protein is a single, non-glycosylated polypeptide chain containing amino acids 105 and having a molecular mass of 11.5 kDa.
Purity: > 95% by SEC-HPLC and SDS-PAGE.
Formulation: The protein (1 ug/ml) contains 20 mM Tris-HCl (pH7.5) 50 mM NaCl and 1 mM EDTA.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other LAIR1 Proteins:
Recombinant Human LAIR1 Protein
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