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Conditions of optimal KIR2DL3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction:
Killer-cell immunoglobulin-like receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.
BP001367-PRO-429: Recombinant Human Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Protein
Source: E. coli-derived.
Recombinant KIR2DL3 protein is a single, non-glycosylated polypeptide chain containing amino acids 23-223 and having a molecular mass of 22.2 kDa. The KIR2DL3 is purified by proprietary chromatographic techniques.
Purity: > 95.0% as determined by RP-HPLC and SDS-PAGE.
Formulation: The protein (1 ug/ml) contains 25 mM Tris- HCl (pH-7.5).
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other KIR2DL3 Proteins:
Recombinant Human KIR2DL3 Protein
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