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Home > Chemicals > Inhibitors, Activators, Antagonists, and Agonists > A-Z Inhibitors, Activators, Antagonists, and Agonists > KB-0742 dihydrochloride (KB0742)

KB-0742 dihydrochloride (KB0742)

KB-0742, KB 0742, CDK9 inhibitor, cyclin-dependent kinase 9

Catalog No. Product Name Size List Price (US$) Quantity
APIM050402 KB-0742 dihydrochloride (KB0742) 5 mg 250.00
APIM050402 KB-0742 dihydrochloride (KB0742) 10 mg 400.00
APIM050402 KB-0742 dihydrochloride (KB0742) 50 mg 960.00
APIM050402 KB-0742 dihydrochloride (KB0742) 100 mg 1500.00
Description

APIM050402: KB-0742 dihydrochloride (KB0742), is an orally bioavailable, potent and selective CDK9 inhibitor with an IC50 of 6 nM"""

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>50mM)
Storage: Store at 0 oC (short term)
desiccated in a tightly
closed container. (Caution: Very Hygroscopic)
Note: Please contact us for COA
50 of 6 nM for CDK9/cyclin T1. KB-0742 dihydrochloride is selective for CDK9/cyclin T1 with >50-fold selectivity over other CDK kinases. KB-0742 d"> and SDS information.

Background Information:

KB-0742 dihydrochloride (CAS No: 2416874-75-2) is a potent

downregulated AR-dependent oncogenic transcription
oral administration of KB-0742 (administered as a 3-day on/4-day off regimen) to mice that had been engrafted with castration resistant prostate cancer cells significantly inhibited tumor growth with modest effects on body weight. In a subsequent mouse xe
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