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Conditions of optimal JAM-A Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
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Introduction
Junctional adhesion molecule A, also known as Junctional adhesion molecule 1, Platelet F11 receptor, Platelet adhesion molecule 1, JAM1, JCAM, F11R, is a single-pass type I membrane protein that Belongs to the immunoglobulin superfamily. F11R contains 2 Ig-like V-type (immunoglobulin-like) domains and Interacts with the ninth PDZ domain. F11R localized at tight junctions of both epithelial and endothelial cells. F11R seems to involve in epithelial tight junction formation. F11R appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. F11R plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. In case of orthoreovirus infection, F11R serves as receptor for the virus.
BP001370-C468: Recombinant Human Junctional adhesion molecule A (JAM-A) Protein
Source: HEK 293-derived.
Recombinant Human Junctional adhesion molecule A (JAM-A) Protein is a secreted protein with sequence (Ser28-Val238) of Human JAM-A fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM Tris-HCl, 50 mM NaCl, 100 mM Glycine, pH 7.5.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other JAM-A Proteins:
Recombinant Human JAM-A Protein
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