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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal IVL Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
Involucrin is a soluble cytoplasmic protein precursor of the epidermal cornfied envelope that becomes cross-linked by transglutaminase during envelope assembly. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea which lacks a distinct cornfied layer. The protein is a useful marker of terminal differentiation. It is tightly linked to the onset of differentiation and first expressed in the immediate suprabasal layers of the epidermis. Involucrin is mapped to 1q21 chromosome, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. Involucrin? structure is composed of a conserved region of about 75 amino acid residues followed by two very variable length segments that contain glutamine-rich tandem repeats. The glutamine residues in the tandem repeats are the substrate for the tranglutaminase in the cross-linking reaction. The size of the protein varies from 285 residues (in dog) to 835 residues (in orangutan).
BP002674-PRO-512: Recombinant Human Involucrin (IVL) protein
Source: Escherichia Coli-derived.
Involucrin Human Recombinant (aa 420-578) expressed in E. coli, shows a 41 kDa band on SDS-PAGE (Including GST tag).
Formulation: Involucrin at 100 ug/ml in 50 mM Tris-HCl, pH 7.5, 10 mM L-glutathione (reduced).
Applications: ELISA, Inhibition Assays, Western Blotting.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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