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Conditions of optimal IRF4 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
IRF4 is a transcriptional activator, belonging to the IRF family. It binds to the interferon- stimulated response element (ISRE) of the MHC Class I promoter (but is not induced by Interferons). IRF4 binds the immunoglobulin lambda light chain enhancer, together with Pu.1. It most likely plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. IRF4 / MUM1 is expressed in the nuclei and cytoplasm of plasma cells and a small percentage of germinal center (GC) B cells mainly located in the "light zone". Its morphologic spectrum ranged from that of centrocyte to that of a plasmablast/plasma cell, and it displayed a phenotype (MUM1+/Bcl-6/Ki67 ) different from that of most GC B cells (MUM1 /Bcl-6+/Ki67+) and mantle B cells (MUM1 /Bcl-6 /Ki67 ).
BP002676-PRO-513: Recombinant Human Interferon regulatory factor 4 (IRF4) protein
Source: Escherichia Coli-derived.
IRF4 is antibody reactive. The IRF4 is fused to a GST tag and purified by proprietary chromatographic techniques.
Formulation: IRF-4 in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA and 20% Glycerol.
Applications: ELISA, Inhibition Assays, Western Blotting.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
IRF4 Antibodies:
IRF4 Polyclonal Antibody
IRF4 Polyclonal Antibody
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