My Cart [ 0 ]
Home > Proteins & Peptides > A-Z Proteins  > IL-32A Protein

IL-32A Protein

Interleukin-32 alpha, TAIFa, IL-32alpha, Interleukin-32, IL-32, Natural killer cells protein 4

Catalog No. Product Name Size List Price (US$) Quantity
BP000155-CYT-648 Recombinant Human IL-32A, His Tag 20 ug 160.00
BP000155-CYT-648 Recombinant Human IL-32A, His Tag 1 mg 2700.00
Description

Introduction
IL-32 is part of the cytokine family and contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. IL-32 expression is elevated after the activation of T-cells by mitogens or the activation of NK cells by IL-2. IL-32 induces the production of TNF-a from macrophage cells. IL-32 pro-inflammatory pathway is activated in response to influenza A virus infection. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.
Induction of TNF, IL-1beta, and IL-6 by IL-32 is intervened by p38-MAPK. IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic, caspase-3-dependent mechanisms. IL32 plays an important role in the pathogenesis of rheumatoid arthritis. IL-32 is involved in activation-induced cell death in T cells, through its intracellular actions. IL-32 is a cell-associated proinflammatory cytokine, which is particularly stimulated by mycobacteria through a caspase-1- and IL-18-dependent production of interferon gamma. IL-32 is associated with TNF-a, IL-1beta, and IL-18. IL32 is involved in human rheumatoid arthritis and is a novel target in autoimmune diseases.

BP000155-CYT-648: Recombinant Human IL-32alpha, His Tag

Source: E. coli-derived.
A single, non-glycosylated, polypeptide chain containing 168 amino acids (1-131 a.a.) and having a molecular mass of 19.1 kDa.
Purity > 95%, by SDS-PAGE and RP-HPLC.
Formulation: The IL-32 His Tag protein solution contains 20 mM Tris-HCl, pH-8, 1 mM DTT and 10% glycerol.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Other IL-32A Protein:
Recombinant Human IL-32α
 

Related Links

See our Privacy Policy