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Home > Proteins & Peptides > A-Z Proteins  > IL-21 Protein

IL-21 Protein

Interleukin-21, Za11

Catalog No. Product Name Size List Price (US$) Quantity
BP000147-CYT-033 Recombinant Rat IL-21 10 ug 160.00
BP000147-CYT-033 Recombinant Rat IL-21 1 mg 4680.00
Description

Introduction
IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (?) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

BP000147-CYT-033: Recombinant Rat IL-21

Source: E. coli-derived.
A single, non-glycosilated polypeptide chain containing 129 amino acids and having a total molecular mass of 15.2 kDa.
The biological activity is measured by its ability to proliferate activated B cells.
Purity: > 95.0% as determined by RP-HPLC and SDS-PAGE.
Formulation: Rat IL-21 was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Reconstitution: It is recommended to reconstitute the lyophilized Rat IL21 in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Other IL-21 Proteins:
Recombinant Mouse IL-21
Recombinant Human IL-21

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