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Human Nectin-3 / CD113 Protein

CD113 antigen; CDw113FLJ90624; DKFZp566B0846; Nectin-3; poliovirus receptor-related protein 3; PPR3; PVRL3; PVRR3

Catalog No. Product Name Size List Price (US$) Quantity
Description

BP003083: Recombinant Human Nectin-3 / CD113 Protein

Source: recombinant human Nectin-3 / CD113 protein (Gly 58 - Asp 400) was expressed in mammalian cells with a His and Avi tag at the C-terminus.
Accession: Q9NQS3
Predicted molecular mass: 40.6 kDa. Due to glycosylation, the recombinant human Nectin-3 / CD113 protein migrates to 68-82 kDa based on the Bis-Tris PAGE result.
Endotoxin: Less than 1 EU per ug by the LAL method.
Formulation: The recombinant human Nectin-3 / CD113 protein was lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
Purity: > 95% by SDS-PAGE and HPLC.

Shipping: The recombinant human Nectin-3 / CD113 protein is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Background

The Nectin family has at least four members (Nectin-1‑4), all of which show alternate splicing, a transmembrane (TM) region (except for Nectin-1 gamma ), and three extracellular Ig-domains. Nectins are highly homologous to the human receptor for poliovirus, and as such, have been alternatively-named poliovirus receptor-related proteins. They do not, however, appear to bind poliovirus. Nectin-3 (also named PRR3, CD113, and PVRL3) is an 83 kDa, type I TM glycoprotein. Its precursor is 549 amino acids (aa) in length. It contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa (aa 405-425), and a cytoplasmic region of 124 amino acids.

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