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Conditions of optimal human Nectin-3 / CD113 protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Source: recombinant human Nectin-3 / CD113 protein (Gly 58 - Asp 400) was expressed in mammalian cells with a His and Avi tag at the C-terminus.
Accession: Q9NQS3
Predicted molecular mass: 40.6 kDa. Due to glycosylation, the recombinant human Nectin-3 / CD113 protein migrates to 68-82 kDa based on the Bis-Tris PAGE result.
Endotoxin: Less than 1 EU per ug by the LAL method.
Formulation: The recombinant human Nectin-3 / CD113 protein was lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
Purity: > 95% by SDS-PAGE and HPLC.
Shipping: The recombinant human Nectin-3 / CD113 protein is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Background
The Nectin family has at least four members (Nectin-1?4), all of which show alternate splicing, a transmembrane (TM) region (except for Nectin-1 gamma ), and three extracellular Ig-domains. Nectins are highly homologous to the human receptor for poliovirus, and as such, have been alternatively-named poliovirus receptor-related proteins. They do not, however, appear to bind poliovirus. Nectin-3 (also named PRR3, CD113, and PVRL3) is an 83 kDa, type I TM glycoprotein. Its precursor is 549 amino acids (aa) in length. It contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa (aa 405-425), and a cytoplasmic region of 124 amino acids.
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