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Conditions of optimal HSF2 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Background
HSF2?HEAT-SHOCK TRANSCRIPTION FACTOR 2??also called HEAT-SHOCK FACTOR 2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. The International Radiation Hybrid Mapping Consortium maps the HSF2 gene to chromosome 6. Mouse Hsf2 was expressed in all 3 embryonic layers at embryonic day 7.5 and that the head fold was strongly stained at embryonic day 8.5. In adults, Hsf2 expression is detected in spermatocytes and spermatogonia, but not in elongated spermatids, spermatozoa, or Sertoli cells. Hsp70i bookmarking is mediated by a transcription factor called HSF2, which binds this promoter in mitotic cells, recruits protein phosphatase-2A, and interacts with the CAPG subunit of the condensin enzyme to promote efficient dephosphorylation and inactivation of condensin complexes in the vicinity, thereby preventing compaction at this site. And Hsf2-null mice were born at the expected mendelian ratio but had brain abnormalities and meiotic and gametogenic defects in both genders.
PA001989-PA1607: HSF2 Polyclonal Antibody
Rabbit Polyclonal Antibody;
Applications: WB: 0.1-0.5 ug/ml IHC-P: 0.5-1 ug/ml .
Reactivity: Human, Mouse, Rat.
Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human HSF2, different from the related rat and mouse sequences by one amino acid.
Purification: Immunogen affinity purified.
Form of Antibody: Lyophilized.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
Other HSF2 Antibodies:
HSF2 Polyclonal Antibody
HSF2 Polyclonal Antibody
HSF2 Protein:
Recombinant Human HSF2 Protein
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