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Conditions of optimal HSD17B8 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Estradiol 17-beta-dehydrogenase 8 (HSD17B8) is a member of the short-chain dehydrogenases/reductases (SDR) family. In mice, the HSD17B8 protein is a 17-beta-hydroxysteroid dehydrogenase which can regulate the concentration of biologically active estrogens and androgens. HSD17B8 is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the HSD17B8 enzyme has some reductive activity and can synthesize estradiol from estrone. HSD17B8 may have a role in biosynthesis of fatty acids in mitochondria.
BP002518-ENZ-108: Recombinant Human Hydroxysteroid (17-beta) Dehydrogenase 8 (HSD17B8) Enzyme
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 281 amino acids (1-261 a.a.) and having a molecular mass of 29.1 kDa. HSD17B8 is fused to a 20 amino acid His-tag at N-terminus.
Purity: > 95.0% as determined by SDS-PAGE.
Formulation: HSD17B8 solution (0.5 mg/ml) containing 20 mM Tris-HCl buffer (pH8.0), 40% glycerol and 150 mM NaCl.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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