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Conditions of optimal HEXIM1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
HEXIM1 expression is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. HEXIM1 is a transcriptional regulator which acts as a universal RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex inhibits RNA polymerase II phosphorylation following transcriptional elongation. HEXIM1 regulates NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
BP002434-PRO-789: Recombinant Human Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) Protein
Source: E. coli-derived.
Recombinant Human HEXIM1 protein is a single, non-glycosylated, polypeptide chain containing 396 amino acids (1-359a.a.) and having a molecular mass of 44.8 kDa. HEXIM1 protein is fused to a 37 amino acid His-Tag at N-Terminus and purified by proprietary chromatographic techniques.
Purity: > 90% by SDS-PAGE.
Formulation: HEXIM1 solution (0.5 mg/ml) containing 20 mM Tris-HCl pH-8, 0.1 M NaCl and 10% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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