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Conditions of optimal Heparinase III Enzyme performance should be determined experimentally by the investigator.
Custom service to make mixture of Heparinases (I, II, and/or III) is available.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Different from heparinase I and heparinase II, Heparinase III enzyme (EC 4.2.2.8) cleaves the glycosidic bond between hexosamines and glucuronic acid residues in non-sulfated regions only which is present in heparan sulfate rather than heparin.
Similar to heparin, located in the extracellular matrix, the glycosaminoglycan of heparan plays important physiological roles in anticoagulation and angiogenesis. The acidic polysaccharide of heparan consists of a heterogeneous disaccharide repeating unit of hexosamine and uronic acid (L-iduronic or D-glucuronic acid) connected through 1-4 linkages and modified with various functional groups. Sulfated regions of heparan sulfate are interspaced with less or non-sulfated regions but heparin sulfate contains no non-sulfated regions.
BP000033-GD7: Recombinant Heparinase III from Flavobacterium heparinum
Source: E. coli-derived.
Specific activity >50 IU/mg. One international unit (IU) of recombinant Heparinase III is defined as the amount of enzyme that will liberate 1.0 umole unsaturated oligosaccharides from heparan sulfate per minute at 30°C and pH 7.3.
Purity >95% by SDS-PAGE.
Molecular weight: 70,800.
Isoelectric point: 9.9 - 10.1.
Form: In hepes buffer with 30% glycerol and 0.01 M Ca2+.
Shipping: Recombinant heparinase III is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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