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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal HDAC1 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
HDAC1 is a member of the histone deacetylase/acuc/apha family and a component of the histone deacetylase complex. HDAC1 is in charge of the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone acetylation and deacetylation, catalyzed by multi-subunit complexes, are a crucial factor in the regulation of eukaryotic gene expression. In addition, HDAC1 interacts with retinoblastoma tumor-suppressor protein and this complex is a major factor in the control of cell proliferation and differentiation. Low levels of HDAC1 were linked to breast cancer progression. Studies have shown that cancer cells successfully maintained decreased levels of pyruvate to prevent inhibition of HDAC1/HDAC3 and thus to escape cell death. HDAC1 is over-expressed in diffuse large B-cell lymphoma and peripheral T-cell lymphoma in opposite to normal lymphoid tissue. The tissue specificity of HDAC1 is ubiquitous, with higher levels in the heart, pancreas and testis, and lower levels in the kidney and brain.
BP000709-ENZ-424: Recombinant Human Histone Deacetylase 1
Source: Hi-5 Baculovirus-derived.
Predicted molecular mass: 56.2 kDa.
Purity > 90%, by RP-HPLC and SDS-PAGE.
Formulation: The HDAC1 solution contains PBS (pH 7.4) and 10% glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other HDAC1 Antibodies:
HDAC1 Polyclonal Antibody
HDAC1 Polyclonal Antibody
HDAC1 Polyclonal Antibody
HDAC1 (Ab-421) Polyclonal Antibody
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