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Conditions of optimal GUCA2B Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Introduction
Prouroguanylin is a 112-amino-acid prohormone precursor of uroguanylin- mature biologically active 16-amino-acid peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases (CG-C) resulting in increased intracellular cGMP levels leading to CFTCR (Cystic Fibrosis Transmembrane Conductance Regulator) activation and subsequent rise in fluid and electrolyte secretion into the lumen.
Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leading to elevated blood pressure independent of the level of diatary salt intake.
Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids.
BP000347-HOR-245: Recombinant Human Prouroguanylin
Source: E. coli-derived.
A 10 kDa protein containing 88 amino acid residues of the human prouroguanylin and 2 additional amino acid residues.
Purity > 95%, by SDS-PAGE and RP-HPLC.
Formulation: filtered and lyophilized from 0.5 ug/ml in 50 mM Phosphate buffer pH-7.4.
Reconstitution: Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely.
Applications: WB, ELISA.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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