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Conditions of optimal GNS Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
N-acetylglucosamine-6-sulfatase, also known as Glucosamine-6-sulfatase, GNS, is a member of the sulfatase family. GNS is required for the lysosomal degradation of the glycosaminoglycans (GAG) heparan sulfate and keratan sulfate. GNS hydrolyzes the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. GNS binds 1 calcium ion per subunit. GNS deficiency are the cause of mucopolysaccharidosis type 3D (MPS3D), an inborn error leading to lysosomal accumulation of heparan sulfate. MPS3D has profound mental deterioration, hyperactivity, and relatively mild somatic manifestations.
BP001518-C354: Recombinant Human N-Acetylglucosamine-6-Sulfatase (GNS) Enzyme
Source: HEK 293-derived.
Recombinant Human N-Acetylglucosamine-6-Sulfatase (GNS) Enzyme is expressed with sequence (Val37 Leu552) of Human GNS fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 EU/ug). .
Formulation: 0.2 um filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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