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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal GDF Protein 15 performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
GDF15 is part of the TGF-Beta superfamily that is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance.
BP000070-CYT-335: Recombinant Human Growth and Differentiation Factor 15 H-Variant
Source: E. coli-derived.
A homodimeric, non-glycosylated, Polypeptide chain containing 2x113 amino acids and having a molecular mass of 24.5 kDa.
The biological activity was assessed by the inhibition of DU-145 cells and was found to be 1-2 ug/ml.
Purity > 95%, by SDS-PAGE and RP-HPLC.
Formulation: GDF15 is lyophilized without additives.
Reconstitution: It is recommended to reconstitute the lyophilized GDF15 in sterile 5 mM AcOH (acetic Acid) at a concentration of 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
GDF15 Antibodies:
GDF15 Polyclonal Antibody
GDF15 Polyclonal Antibody
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