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Conditions of optimal FST Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).
BP000104-CYT-232: Recombinant Human Follistatin
Source: E. coli-derived.
N-terminal sequence analysis: Gly-Asn-Cys-Trp-Leu.
Predicted molecular mass: 31.5 kDa.
The activity is determined by the ability to neutralize Activin A inhibitory effect of mouse MPC-11 cells. The expected ED50 is 100-400 ug/ml corresponding to a Specific Activity of 2,500-10,000 IU/mg in the presence of 7.5 ug/ml Activin A.
Purity > 95%, by SDS--PAGE and RP-HPLC.
Formulation: Lyophilized from a concentrated (1 ug/ml) solution containing no additives.
Reconstitution: It is recommended to reconstitute the lyophilized Follistatin in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
FST Antibody:
FST Polyclonal Antibody
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