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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal FGF 23 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
FGF-23 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-23 inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of FGF23 was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations FGF23 have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
BP000186-CYT-020: Recombinant Human FGF 23
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing a total of 228 amino acids and having a molecular mass of 22.5 kDa.
The biological activity was measured in a cell proliferation assay using NIH/3T3 mouse embryonic fibroblasts. The ED50 for this effect is typically 0.05-0.5 ug/ml in the presence of 5 ug/ml of Recombinant Mouse Klotho and 10 ug/ml of heparin.
Purity > 95%, by SDS-PAGE.
Formulation: The FGF-23 protein (0.5 ug/ml) was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Reconstitution: It is recommended to reconstitute the lyophilized FGF-23 in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other FGF23 Proteins:
Recombinant Human FGF 23, His Tag
Recombinant Human FGF 23 C-Terminal
FGF23 Antibody:
FGF23 Polyclonal Antibody
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