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Home > Antibodies > Research-Grade Biosimilars > Etanercept Biosimilar

Etanercept Biosimilar

TNF Inhibitor, Tumor Necrosis Factor Alpha Inhibitor

Catalog No. Product Name Size List Price (US$) Quantity
C075P Etanercept Biosimilar 1 mg 175.00
C075P Etanercept Biosimilar 5 mg 600.00
C075P Etanercept Biosimilar 20 mg 1200.00
Description

What is research grade Etanercept biosimilar? Research grade Etanercept biosimilar has the same amino acid sequence as Etanercept (trade name Enbrel), a fusion protein of the soluble TNF receptor 2 and a Fc fragment (human IgG1 isotype). Etanercept can be used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. TNF alpha is the "master regulator" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has the potential to treat these diseases by inhibiting TNF alpha. Etanercept binds to TNF alpha and decreases its role in disorders involving excess inflammation in humans and other animals, including autoimmune diseases such as ankylosing spondylitis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and, potentially, in a variety of other disorders mediated by excess TNF alpha.

C075P: Etanercept Biosimilar

Recombinant protein composed of the soluble TNF receptor 2 fused with the Fc region of human immunoglobulin gamma 1 (hIgG1).
Source: The etanercept biosimilar protein was produced in the Enbrel biosimilar CHO stable cell line.
Specificity/Sensitivity: The etanercept biosimilar protein specifically binds to the human TNF alpha.
Applications: Functional assays, and those assays for studying biological pathways affected by etanercept.
Form of Protein: 0.2 uM filtered solution, pH 7.1 to 7.7, no stabilizers or preservatives.
Endotoxin: <1 EU/mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The research grade etanercept biosimilar protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

Syd Labs provides the following research grade anti-TNF alpha antibody biosimilars:
Infliximab biosimilar, research grade, anti-human TNF alpha monoclonal antibody
Adalimumab biosimilar, research grade, anti-human TNF alpha monoclonal antibody

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