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The research grade etanercept biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls and recombinant hIgG1 Fc proteins are available.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
What is research grade Etanercept biosimilar? Research grade Etanercept biosimilar has the same amino acid sequence as Etanercept (trade name Enbrel), a fusion protein of the soluble TNF receptor 2 and a Fc fragment (human IgG1 isotype). Etanercept can be used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. TNF alpha is the "master regulator" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has the potential to treat these diseases by inhibiting TNF alpha. Etanercept binds to TNF alpha and decreases its role in disorders involving excess inflammation in humans and other animals, including autoimmune diseases such as ankylosing spondylitis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and, potentially, in a variety of other disorders mediated by excess TNF alpha.
C075P: Etanercept Biosimilar
Recombinant protein composed of the soluble TNF receptor 2 fused with the Fc region of human immunoglobulin gamma 1 (hIgG1).
Source: The etanercept biosimilar protein was produced in the Enbrel biosimilar CHO stable cell line.
Specificity/Sensitivity: The etanercept biosimilar protein specifically binds to the human TNF alpha.
Applications: Functional assays, and those assays for studying biological pathways affected by etanercept.
Form of Protein: 0.2 uM filtered solution, pH 7.1 to 7.7, no stabilizers or preservatives.
Endotoxin: <1 EU/mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The research grade etanercept biosimilar protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Syd Labs provides the following research grade anti-TNF alpha antibody biosimilars:
Infliximab biosimilar, research grade, anti-human TNF alpha monoclonal antibody
Adalimumab biosimilar, research grade, anti-human TNF alpha monoclonal antibody
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