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Background Information:
A selective inhibitor for the Epidermal Growth Factor Receptor (EGFR) tyrosine kinases.
Reference:
1. J.R. Johnson et al. Approval Summary for Erlotinib for Treatment of Patients with Locally Advanced or Metastatic Non–Small Cell Lung Cancer after Failure of at Least One Prior Chemotherapy Regimen. Clin. Can. Res. 2005, 11, 6414-6421.
2. J. Porter et al. A dose escalation and pharmacokinetic (PK) trial of weekly docetaxel combined with daily erlotinib in adult cancer patients. J. Clin. Oncol. 2004, 22, 14S, 2119.
APIM050144: ERLOTINIB
CAS No.: 183321-74-6.
Molecular Formula: C22H23N3O4 · HCl.
Molecular Weight: 429.95.
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: HPLC, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO and water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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