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Conditions of optimal ErbB3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
ErbB3, also called Her3 (human epidermal growth factor receptor 3), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. Among ErbB family members, ErbB3 is unique in that it contains a defective kinase domain. ErbB3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric ErbB3 serves as a low affinity receptor for the heregulins (HRG). ErbB3 can induce specific antibody production in vivo, hence to inhibit tumor cell growth. ErbB-3 can be used to treat early, medium and advanced or post-operative breast cancer with over-expression of ErbB2. According to its mechanism of action, ErbB3 is classified as a therapeutic for cancer.
BP000972-PKA-342: Recombinant Human Tyrosine Kinase ErbB-3
Source: E. coli-derived.
A single, non-glycosylated, fusion polypeptide chain containing Thyrodoxin Tag and His tag. The protein consists of 190 amino acids (Met1- Cys190) and having a total molecular mass of 34 kDa.
Measured by its ability to postpone tumor emerge time of spontaneous breast cancer in FVB/N transgenic mice and inhibit the development of tumor, effectively inhibit the growth of in situ transplanted breast cancer in FVB/N transgenic mice.
Purity > 95%, by RP-HPLC and SDS-PAGE.
Formulation: Each mg protein contains 1 mg aluminum hydroxide 10 mM arginine, 10 mM sodium chloride, 20 mM sodium phosphate buffer and 5 mM potassium phosphate.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
ErbB3 Antibodies:
ERBB3 Polyclonal Antibody
HER3 Polyclonal Antibody
HER3 (Ab-1328) Polyclonal Antibody
HER3 (Ab-1289) Polyclonal Antibody
HER3 (Ab-1222) Polyclonal Antibody
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