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Conditions of optimal Epo-R antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Background
EPOR (Erythropoietin Receptor), is a protein that in humans is encoded by the EPOR gene. Jones et al. (1990) isolated the human homolog of the murine erythropoietin receptor (EPOR) from an erythroleukemia cell line and from fetal liver. Budarf et al. (1990) mapped the EPOR gene to human 19pter-q12 by somatic cell hybrid analysis. Akashi et al. (2000) reported the prospective identification, purification, and characterization, using cell surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloid lineages. The distinction between the common lymphoid progenitor and common myeloid progenitor is that the common lymphoid progenitor expresses IL7 receptor and does not express MPL, whereas the common myeloid progenitor does not express the IL7 receptor and expresses MPL. Becker et al. (2010) showed by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of the cell surface receptor are characteristic features of the EPO receptor.
PA001596-B0917: Epo-R (Ab-368) Polyclonal Antibody
Rabbit Polyclonal Antibody.
Specificity/Sensitivity: Epo-R (Ab-368) antibody detects endogenous levels of total Epo-R protein.
Applications: WB: 1:500~1:1000 IF: 1:500~1:1000 ELISA: 1:5000.
Reactivity: Human, Mouse, Rat.
Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Epo-R around the phosphorylation site of tyrosine 368 (D-T-YP-L-V).
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form of Antibody: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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