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Conditions of optimal Eotaxin 2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
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Introduction
Eotaxin-2 selectively chemoattracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Furthermore, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which includes C-terminal truncation, contains 78 amino acids (92 amino acids for the mouse homolog, without C-terminal truncation).
CCL24 functions as a chemotactic chemokine for resting t-lymphocytes, and eosinophils. CCL24 has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. CCL24 is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line and binds to CCR3.
BP000263-CHM-238: Recombinant Human Eotaxin-2 (CCL24)
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 78 amino acids and having a molecular mass of 8.8 kDa.
The activity is determined by the chemoattract of human PBE (peripheral blood eosinophils) at a concentration between 50-100 ug/ml corresponding to a Specific Activity of 10,000-20,000 IU/mg.
Purity > 97%, by SDS-PAGE and RP-HPLC.
Formulation: The CCL24 protein was lyophilized from a concentrated (1 ug/ml) sterile solution containing 20 mM PBS pH-7.4 and 0.15 M sodium chloride.
Reconstitution: It is recommended to reconstitute the lyophilized CCL24 Human Recombinant in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other Eotaxin 2 Proteins:
Recombinant Rat Eotaxin-2 (CCL24)
Recombinant Mouse Eotaxin-2 (CCL24)
Eotaxin 2 Antibody:
Eotaxin-2 Monoclonal Antibody
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