Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Catalog No. | Product Name | Size | List Price (US$) | Quantity |
---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
EMD1214063 (Tepotinib) is an orally bioavailable, potent and selective inhibitor of c-Met, inhibiting the enzyme with an IC50 value of 3 nM, highly selective (≥ 1000-fold) over a panel of 242 other kinases; inhibits c-Met phosphorylation and downstream signaling targets in various cancer cell lines with IC50s of 6-9 nM; demonstrates in vivo antitumor efficacy in mouse xenograft models (ref 1).
Reference:
1. F. Bladt, et al, EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clinical Cancer Research 19(11), 2941-2951 (2013).
APIM050143: EMD1214063 (TEPOTINIB)
CAS No.: 1100598-32-0.
Molecular Formula: C29H28N6O2.
Molecular Weight: 492.6.
Purity: 99% (HPLC).
QC: LC/MS, 1HNMR.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.