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EMD1214063 (TEPOTINIB)

EMD-1214063, MSC2156119
Catalog No. Product Name Size List Price (US$) Quantity
APIM050143 EMD1214063 (TEPOTINIB) 5 mg 175.00
APIM050143 EMD1214063 (TEPOTINIB) 10 mg 280.00
APIM050143 EMD1214063 (TEPOTINIB) 50mg 795.00
APIM050143 EMD1214063 (TEPOTINIB) 100 mg 1350.00
Description

Background Information:

EMD1214063 (Tepotinib) is an orally bioavailable, potent and selective inhibitor of c-Met, inhibiting the enzyme with an IC50 value of 3 nM, highly selective (≥ 1000-fold) over a panel of 242 other kinases; inhibits c-Met phosphorylation and downstream signaling targets in various cancer cell lines with IC50s of 6-9 nM; demonstrates in vivo antitumor efficacy in mouse xenograft models (ref 1).

Reference:

1. F. Bladt, et al, EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clinical Cancer Research 19(11), 2941-2951 (2013).

APIM050143: EMD1214063 (TEPOTINIB)

CAS No.: 1100598-32-0.
Molecular Formula: C29H28N6O2.
Molecular Weight: 492.6.
Purity: 99% (HPLC).
QC: LC/MS, 1HNMR.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

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