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Background Information:
Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor and a novel cytotoxic agent. It inhibits CDK2, CDK5, CDK1, and CDK9 activity in vitro with IC50 values of 1, 1, 3, and 4 nM, respectively. It exhibits superior activity, compared with flavopiridol, with a much improved therapeutic index. It is currently in clinical trials.
Reference:
1. D. Parry, et al, Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor, Mol Cancer Ther, 2010, 9(8); 2344–53.
2. K. Paruch, et al, Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases, ACS Med. Chem. Lett., 2010, 1 (5), pp 204–208.
3. G. Feldmann, et al, Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models, Cancer Biol. Ther. 2011, 12(7), 598-609.
APIM050142: DINACICLIB
CAS No.: 779353-01-4.
Molecular Formula: C21H28N6O2 ? 1/2 H2O.
Molecular Weight: 405.5.
Purity: >99.5% Chem and Optical Purity by achiral and chiral HPLCs.
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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