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Conditions of optimal DDIT3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
DDIT3 reduces DNA-binding activity of C/EBP and lap by forming heterodimers which don? bind DNA. DDIT3, also known as GADD153, is a basic domain-leucine zipper (bZIP) transcription factor of C/EBP family. DDIT3 protein is up-regulated by several stresses, such as amino acid or glucose starvation, endoplasmic reticulum (ER) stress, osmotic stress and hypoxia. DDIT3 protein is invloved in ER stress-mediated apoptosis and in disease including diabetes, brain ischemia and neurodegenerative disease. DDIT3 plays a role in asoprisnil-induced apoptosis. Hypoglycaemia-induced necrotic cell death of neuroblastoma cells is an active process mediated via the induction of the transcription factor DDIT3. DDIT3 plays an important role in melanoma progression. HRG stimulation of mammary epithelial cells induces the expression of DDIT3 mRNA and protein and transcription of DDIT3 promoter.
BP001938-PRO-638: Recombinant Human DNA Damage Inducible Transcript 3 (DDIT3) Protein
Source: E. coli-derived.
Recombinant Human DDIT3 protein is a single, non-glycosylated polypeptide chain containing 189 amino acids and having a molecular mass of 21 kDa. Recombinant Human DDIT3 protein is fused to a 20 amino acids His tag at N-terminus. Recombinant Human DDIT3 protein is purified by proprietary chromatographic techniques.
Purity: > 90.0% as determined by: (a) Analysis by RP-HPLC; (b) Analysis by SDS-PAGE.
Formulation: The DDIT3 protein solution (1 mg/ml) contains 20 mM Tris-HCl pH-8 and 20% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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