Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
CUDC-305 (DEBIO-0932) is an orally bioavailable inhibitor of Heat Shock Proteins, displaying high affinity for HSP90α/β (about 100 nM in IC50) and HSP90 complex derived from cancer cells (IC50= 48.8 nM). Exhibits high oral bioavailability (96.0%) and selective retention in tumor (half-life, 20.4 hours) compared with normal tissues. BBB Penetrant.
Reference:
1. R. Bao, et al, Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer, Mol Cancer Ther. 2009 Dec; 8(12), 3296-306.
2. R. Bao, et al, CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy, Clin Cancer Res. 2009 Jun 15; 15(12), 4046-57.
APIM050350: CUDC-305 (DEBIO-0932)
CAS No.: 1061318-81-7.
Molecular Formula: C22H30N6O2S.
Molecular Weight: 442.58.
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO, and water with 2 eq. of acid.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.