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Conditions of optimal CDNF Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
CDNF is a member of the ARMET family and acts as a trophic factor for dopamine neurons. CDNF inhibits the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When CDNF controlled after 6-OHDA-lesioning, it reestablishes the dopaminergic function and inhibits the degeneration of dopaminergic neurons in substantia nigra. CDNF is universally expressed in neuronal and non-neuronal tissues. The highest levels in the brain are found in the optic nerve and corpus callosum.
BP002477-CYT-167: Recombinant Human Cerebral Dopamine Neurotrophic Factor (CDNF) Protein
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 161 amino acids and having a molecular mass of 18.5 kDa.
Fully biologically active when compared to standard. The ED50 as determined by its ability to stimulate the proliferation of rat C6 cells is 15-25 ug/ml, corresponding to a specific activity of 40-67 units/mg.
Purity: > 96.0% as determined by RP-HPLC and SDS-PAGE.
Formulation: CDNF protein was lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4.
Reconstitution: It is recommended to reconstitute the lyophilized CDNF in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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