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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal CDK8 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
CDK8 (cyclin-dependent kinase 8; protein kinase K35; CDK8 protein kinase; cell division protein kinase 8; K35) is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
BP002452-PKA-310: Recombinant Human Cyclin-Dependent Kinase 8 (CDK8) Enzyme
Source: E. coli-derived.
A full-length protein fused to a proprietary 16-Kd tag (a 6xHis tag is located at the very N-terminal end).
Purity: > 90% as determined by SDS-PAGE.
Formulation: CDK8 is supplied at 0.1 mg/ml in a buffer containing 25 mM HEPES, pH 7.9, 125 mM KCI, 0.5% TX-100 and 50% glycerol.
Applications: WB, ELISA.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
CDK8 Antibodies:
CDK8 Polyclonal Antibody
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