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Conditions of optimal CDK2 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Cyclin-dependent kinase 2 (CDK2) belongs to the cyclin-dependent kinase of Ser/Thr protein kinase. CDK2 acts as a catalytic subunit of the cyclin dependent kinase complex, whose activity is restricted to the G1-S phage of the cell cycle, it is essential for the G1/S transition. The kinase activity of CDK2 can be regulated by the association with a cyclin subunit, its phosphorylation state and CDK inhibitors. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Try14 and Tyr15. The inhibition of CDK2-cyclin complex can also be attributed to association with p27Kip1 and p21Waf1/Cip1. The activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells, such as neurons, thymocytes and endothelial cells.
BP001684-PKA-008: Recombinant Human Cyclin-Dependent Kinase 2 (CDK2) Protein
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 306 amino acids (1-298 a.a.) and having a molecular mass of 35 kDa. CDK2 is fused to an 8 amino acid His-tag at C-terminus.
Purity: > 95% by SDS-PAGE.
Formulation: CDK2 protein solution (0.5 mg/ml) containing 20 mM Tris-HCl buffer (pH8.0), 20% glycerol and 1 mM DTT.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other CDK2 Enzymes:
Recombinant Human CDK2 Protein
CDK2 Antibodies:
CDK2/CDC2 (Ab-160) Polyclonal Antibody
CDK2 Polyclonal Antibody
CDK2 Polyclonal Antibody
CDK2 Polyclonal Antibody
CDK2 (Phospho-Thr160) Polyclonal Antibody
CDK2 (Ab-160) Polyclonal Antibody
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