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Conditions of optimal C5a Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
Complement C5 (C5a) is a glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 77 amino acid peptide that is created by the C5a convertase proteolytic cleavage of C5 ?chain in the classical and alternative complement pathway (C4b2a3b, C3bBb3b). Mouse C5a has four?helices, plus three intra-chain disulfide bonds that form a triple loop structure. C5a functions via G-protein coupled receptor (GPCR) (C5aR/CD88). C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial, smooth muscle, kidney, liver, and neural cells. It mediates IL-8 release from bronchial epithelial cells. It also triggers an oxidative burst in macrophages and neutrophils, causing release of histamine in basophils and mast cells. C5a anaphylatoxin activity on hepatocytes results indirectly from interaction with nonparenchymal cell via prostanoid secretion. Mouse C5a shares 60% and 82% sequence identity to human and rat C5a, respectively
BP001665-PRO-085: Recombinant Mouse Complement C5 (C5a) Protein
Source: E. coli-derived.
N-terminal sequence analysis: Asn-Leu-His-Leu-Leu.
Predicted molecular mass: 9 kD.
Purity: > 95.0% by reducing RP-HPLC and reducing SDS-PAGE.
Formulation: Recombinant Mouse C5a protein was lyophilized from a concentrated (1 ug/ml) solution in 20 mM PB, pH 7.5 and 350 mM NaCl.
Reconstitution: It is recommended to reconstitute the lyophilized Mouse C5a in sterile 18 M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other C5a Proteins:
Recombinant Mouse C5a Protein
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