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Conditions of optimal BMP 7 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
BP000067-CYT-276: Recombinant Human BMP7, CHO
Source: Chinese Hamster Ovarian Cells-derived.
N-TERMINAL-Human BMP-2 (Met 1 - Arg 282) Human BMP-7 (Ser 293 - Arg 431)-C-TERMINAL. The DNA sequence encoding the human BMP-2 signal peptide and propeptide (1~282 amino acid) fused to the human rhBMP-7 mature chain (293~431 amino acid) was expressed in a Chinese hamster ovary cell line. The mature recombinant BMP-7 generated by the proteolytic removal of the signal peptide and propetide contains 139 amino acid residues. The glycosylation of BMP-7 increases the molecular mass and the glycosylated proteins migrate as 25 ~ 40 kDa.
Measured in alkaline phosphatase activity assay using MC3T3-E1 cells. The ED50 for this effect is <100 ug/ml, corresponding to a Specific Activity of 10,000 IU/mg.
Purity > 97%, by SDS-PAGE and RP-HPLC.
Formulation: Lyophilized from a concentrated (1 ug/ml) sterile solution containing 1% sucrose, 1.2% mannitol, 20 mM glycine, and 0.05% tween 20 pH-4.
Reconstitution: It is recommended to reconstitute the lyophilized Bone Morphogenetic Protein-7 in 1 ml sterile/ endotoxin free water.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other BMP 7 Proteins:
Recombinant Human BMP7, His Tag
Recombinant Human BMP7
Recombinant Human BMP7, Plant
BMP7 Antibody:
BMP7 Monoclonal Antibody
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