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Conditions of optimal BLOC1S5 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
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Introduction
Muted homolog (MUTED) is a component of the BLOC-1 complex, a complex which is necessary for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. The BLOC-1 complex is needed to steer membrane protein cargos into vesicles assembled at cell bodies for release into neurites and nerve terminals. In addition, this complex, along with SNARE proteins, is suggested to be involved in neurite extension. MUTED also interacts with pallidin, dystrobrevin binding protein 1 and CNO/cappuccino. MUTED is ubiquitously expressed with higher levels in the brain, bone marrow, kidney, and liver and lower levels in the skeletal muscle.
BP001564-PRO-1155: Recombinant Human Biogenesis of Lysosomal Organelles Complex-1, Subunit 5 (BLOC1S5) Protein
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 210 amino acids (1-187 a.a) and having a molecular mass of 24 kDa. BLOC1S5 is fused to a 23 amino acid His-tag at N-terminus.
Purity: > 90.0% as determined by SDS-PAGE.
Formulation: BLOC1S5 protein solution (0.25 mg/ml) containing 20 mM Tris-HCl buffer (pH 8.0), 0.1 M NaCl, 40% glycerol, 2 mM DTT, 0.1 mM PMSF and 1 mM EDTA.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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